Surgical Treatment of Sporadic Pancreatic Neuroendocrine Tumors: A State of the Art Review

Table 2

Pathology report recommendations for pancreatic neuroendocrine tumors (PNETs) [4].

Macroscopic description
(i) Exact anatomical site
(ii) Margins distance
(iii) Size of the lesion
Microscopic description
(i) Description inclusive of all relevant aspects according to specific anatomical site (structure, necrosis, etc.)
(ii) Supporting immunohistochemistry
(iii) Mitotic count per 10 HPF (2 mm^2) and number of mitoses assessed in 50 HPF
(iv) Ki-67 index per 400–2,000 cells (hot spots)
(v) Node status
(vi) Margins status
Diagnosis
(i) Definition (NET or NEC)
(ii) Cell component (functioning cases only)
(iii) Grade (1, 2, or 3)
(iv) Tumor-node-metastasis stage

HPF: high-power field; NEC: neuroendocrine carcinoma; NET: neuroendocrine tumor.