Surgical Treatment of Sporadic Pancreatic Neuroendocrine Tumors: A State of the Art Review

Table 3

Key points.

Key points
(i) Surgical resection is the only curative treatment for patients with PNETs.
(ii) The incidence of PNETs has increased during the last decades.
(iii) PNETs are clinically diverse and divided in functioning and nonfunctioning disease.
(iv) The ENETS TNM staging system is superior to the UICC/AJCC/WHO 2010 TNM staging system in terms of prognostic stratification for patients with PNETs.
(v) There has been a trend towards more aggressive surgery as well as more minimally invasive surgery in patients with PNETs over the last decade.
(vi) Lymph node sampling should be performed routinely after curative resection of PNETs, as lymph node ratio is a significant predictor of recurrence.
(vii) The five- and 10-year survival rates for all PNETs are about 65% and 45%.
(viii) Long-term followup of patients having undergone surgical treatment for nonfunctioning PNETs is essential due to the risk of late recurrence.