The Involvement of Angiotensin Type 1 and Type 2 Receptors in Estrogen-Induced Cell Proliferation and Vascular Endothelial Growth Factor Expression in the Rat Anterior Pituitary
Figure 5
Immunohistochemical staining for vascular endothelial growth factor (VEGF) in anterior pituitary of rats; (a) control diethylstilboestrol- (DES-) untreated group, (b) control DES-treated group, (c) DES and AT1 blocker (losartan) cotreated group, (d) DES and AT2 blocker (PD12319) co-treated group, and (e) DES and angiotensin converting enzyme inhibitor (captopril) cotreated group. The white arrows indicate the single-VEGF-positive pituitary cell, the black arrow indicates the VEGF immunopositive blood vessel, within the black rectangular: the example isle of VEGF immunopositive cells in rat anterior pituitary.
