The Scientific World Journal

Research Article

Antitumor and Immunopotentiating Activity of Polysaccharide PST001 Isolated from the Seed Kernel of Tamarindus indica: An In Vivo Study in Mice

Table 3

Tumor and hematological characteristics in mice injected with drug for 7 days, DLA administered on 8th day, observed for 21 days, and dissected on 22nd day (Group 4).
ConcentrationDLA controlPST 200 mg/kgCTX 50 mg/kgPST + CTX
Tumor volume (mL)9 ± 0.54 ± 0.61*** 3 . 6 ± 0 . 9 6 *** 3 . 1 ± 0 . 5 8 ***
Body weight (g) 3 5 . 1 2 ± 1 . 5 3 1 . 5 9 ± 2 . 3 * 2 8 . 9 7 ± 1 . 3 ** 2 6 . 8 ± 1 . 4 **
PCV (mL) 3 . 1 ± 0 . 6 0 . 9 ± 0 . 0 5 *** 0 . 8 ± 0 . 0 5 *** 0 . 6 ± 0 . 0 7 **
Mean survival time (Days)23 ± 0.8738 ± 0.99***43 ± 0.91***54 ± 1***
% Increase in life span (ILS)— 6 5 . 2 1 ± 0 . 6 7 *** 8 6 . 9 5 ± 0 . 8 3 *** 1 3 4 . 7 8 ± 0 . 7 9 ***
Tumor cell count (106 cells/mL)147 ± 0.2142 ± 0.6***28 ± 0.95***25 ± 0.3***
Percentage of viable cells94 ± 173 ± 1.7***68 ± 2***64 ± 2***
Percentage of nonviable cells6 ± 127 ± 2***32 ± 1***36 ± 2***
Hb (G%) (12.2–16.2) gm/dL 7 . 9 ± 0 . 3 6 8 . 3 ± 0 . 3 6 n s   9 . 6 ± 0 . 7 9 * 1 2 . 6 ± 0 . 7 9 ***
RBC (Million/cmm) (7–12.5) × 106/mm3 2 . 7 ± 0 . 7 2 2 . 8 ± 0 . 6 5 n s 3 . 3 ± 0 . 6 n s   4 . 6 ± 0 . 7 2 *
TC (c/mm) (5100–11600)16900 ± 36012400 ± 300***10500 ± 150***9000 ± 100***
Platelets (/cmm) (160000–410000)135000 ± 500150000 ± 430***195000 ± 600***210000 ± 550***
Data were expressed as mean ± SD ( 𝑛 = 6 ) on day 22 of the experiment. Statistically significant differences are at * 𝑃 < 0 . 0 5 , ** 𝑃 < 0 . 0 1 , *** 𝑃 < 0 . 0 0 1 ; ns is the non-significant, as compared with control group.