Antitumor and Immunopotentiating Activity of Polysaccharide PST001 Isolated from the Seed Kernel of Tamarindus indica: An In Vivo Study in Mice
Table 4
Tumor and hematological characteristics in mice injected with EAC on day 1 followed by drug administration for 14 days and dissected on 15th day (Group 2).
Concentration
EAC control
PST 200 mg/kg
5-FU 20 mg/kg
PST + 5-FU
Tumor volume(mL)
***
***
***
Body weight (g)
*
**
**
PCV(mL)
***
***
***
Mean survival time (Days)
19 ± 0.98
28 ± 0.99***
33 ± 1***
38 ± 1.7***
% Increase in life span (ILS)
—
***
***
100 ± 1***
Tumor cell count (106 cells/mL)
175 ± 2
58 ± 1***
39 ± 1.3***
32 ± 1***
Percentage of viable cells
93 ± 1
75 ± 2***
70 ± 0.5***
68 ± 1***
Percentage of nonviable cells
7 ± 1
25 ± 0.57**
30 ± 2**
32 ± 1***
Hb (G%) (12.2–16.2) gm/dL
11 ± 0.5
RBC (Million/cmm) (7–12.5) × 106/mm3
3.6 ± 1
TC (c/mm) (5100–11600)
17500 ± 600
10100 ± 550***
9300 ± 300***
8200 ± 150***
Platelets (/cmm) (160000–410000)
203000 ± 150
250000 ± 235***
301000 ± 195***
350000 ± 210***
Data were expressed as mean ± SD () on day 15 of the experiment. Statistically significant differences are at *, **, ***; ns is the non-significant, as compared with control group.