Antitumor and Immunopotentiating Activity of Polysaccharide PST001 Isolated from the Seed Kernel of Tamarindus indica: An In Vivo Study in Mice

Table 5

Tumor and hematological characteristics in mice injected with drug for 7 days, EAC administered on 8th day, observed for 21 days and dissected on 22nd day (Group 4).

Concentration	EAC Control	PST 200 mg/kg	5-FU 20 mg/kg	PST + 5-FU
Tumor volume (mL)	9.7±0.2	4.4±0.34 ***	3.3±0.6 ***	2.9±0.29 ***
Body weight (g)	34.91±1.9	30.8±1.2 **	26.21±2.3 **	25.12±2.7 **
PCV (mL)	3 ± 0.45	1.2±0.1 ***	0.8±0.1 ***	0.6±0.2 ***
Mean survival time (Days)	20 ± 1	33 ± 2***	44 ± 0.57***	56 ± 1***
% Increase in life span (ILS)	—	65 ± 1***	120 ± 2***	180 ± 1***
Tumor cell count (10^6 cells/mL)	173 ± 0.43	51 ± 0.36***	29 ± 0.5***	25 ± 0.36***
Percentage of viable cells	92 ± 1	70 ± 2***	64 ± 0.57**	60 ± 1**
Percentage of nonviable cells	8 ± 1	30 ± 0.57***	36 ± 1***	40 ± 2***
Hb (G%) (12.2–16.2) gm/dL	7.2±0.8	9.8±1 *	12 ± 1.4***	14 ± 1.9***
RBC (Million/cmm) (7–12.5) × 10^6/mm^3	2.7±0.4	3.6±0.9^ns	4.3±1.3^ns	5.1±1.6 **
TC (c/mm) (5100–11600)	18800 ± 100	11100 ± 50***	8500 ± 75***	8000 ± 60***
Platelets (/cmm) (160000–410000)	115000 ± 450	170000 ± 525***	200000 ± 550***	230000 ± 490***

Data were expressed as mean ± SD (𝑛=6) on day 22 of the experiment. Statistically significant differences are at *𝑃<0.05, **𝑃<0.01, ***𝑃<0.001; ns is the non-significant, as compared with control group.