Antitumor and Immunopotentiating Activity of Polysaccharide PST001 Isolated from the Seed Kernel of Tamarindus indica: An In Vivo Study in Mice

Table 6

Effect of PST001 on haematological parameters in mice.

	Control	100 mg/kg PST001	200 mg/kg PST001	400 mg/kg PST001
(1) Hb (g/dL)	12.8±0.25	13.4±0.84^ns	12.3±1.13^ns	12.1±1.41^ns
(2) Total WBC count (cells/mm^3)	5,100 ± 212	9,100 ± 141***	8400 ± 176***	8300 ± 127***
(3) Differential count
(1) Polymorphoneutrophils (%)	50 ± 2.82	45 ± 2.12 **	42 ± 1.41***	41 ± 1.13***
(2) Lymphocytes (%)	47 ± 2.40	52 ± 1.41*	54 ± 2.26***	55 ± 2.54*
(3) Eosinophils (%)	3 ± 0.70	3 ± 0.28*	4 ± 0.42*	4 ± 0.84***
(4) Platelet (cells/mm^3)	3,40,000 ± 282	3,53,000 ± 777***	3,62,000 ± 707***	3,83,000 ± 636***
(5) RBC (Cells/Ml × 10^6)	4.7±0.07	4.9±0.08 ***	5.1±0.02 ***	5.4±0.04 ***

Data were expressed as mean ± SD (𝑛=6) on day 15 of the experiment. Statistically significant differences are at *𝑃<0.05, **𝑃<0.01, ***𝑃<0.001; ns is non-significant, when compared between control, 100 mg/kg PST001, 200 mg/kg PST001, and 400 mg/kg PST001 using Tukey’s multiple comparison’s test (Graph Pad Prism 4.0). Hb: Hemoglobin; RBC: Red Blood Corpuscles.