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The Scientific World Journal
Volume 2012 (2012), Article ID 379360, 6 pages
http://dx.doi.org/10.1100/2012/379360
Research Article

Antioxidant Effect of MnTE-2-PyP on Lung in Asthma Mice Model

1Sector of Clinical Immunology and Allergology, Pelven Medical University, 5800 Pleven, Bulgaria
2Sector of Disaster Medicine, Pelven Medical University, 5800 Pleven, Bulgaria
3Sector of Clinical and Experimental Pharmacology, Pelven Medical University, 5800 Pleven, Bulgaria

Received 20 October 2011; Accepted 28 December 2011

Academic Editors: R. Álvarez-Sala and F. Arancibia

Copyright © 2012 Lyudmil Terziev et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Aim. To investigate the effects of MnTE-2-PyP on some markers of antioxidant defence system in asthma mice model. Material and Methods. The animals were divided into four groups: group 1, controls; group 2, injected with ovalbumin, group 3, treated with MnTE-2-PyP, and group 4, treated with ovalbumin and MnTE-2-PyP. The activities of superoxide dismutase, catalase, glutathione peroxidase and nonprotein sulfhydryl groups content (NPSH) were determined in lung homogenate. Results. The activities of superoxide dismutase and catalase in group 2 decreased significantly as compared to control group. The decrease of the same enzymes in group 4 was lower and significant as compared to group 2. Changes in the glutathione peroxidase activity showed a similar dynamics. The NPSH groups content decreased in group 2. In group 4 this decrease was relatively lower as compared to group 2. Conclusions. The application of MnTE-2-PyP mitigated the effects of oxidative stress in asthma mice model.