Effect of Potent Ethyl Acetate Fraction of Stereospermum suaveolens Extract in Streptozotocin-Induced Diabetic Rats

Table 1

Effect of various fraction of ethanol extract of Stereospermum suaveolens on glucose level by acute treatment in STZ-induced diabetic rat.

Groups	0 h	1/2 h	1 h	2 h	4 h	5 h
Normal (5% DMSO in 0.9% NaCl, 5 mL /kg )	84.16 ± 2.34	85.00 ± 2.68	87.73 ± 2.21	90.23 ± 2.05	89.13 ± 2.34	83.83 ± 2.44
STZ-induced diabetic control (40 mg/kg)	294.65 ± 1.86 ^a,**	300.21 ± 3.57^a,**	302.25 ± 6.10^a,**	298.16 ± 5.31^a,**	299.56 ± 6.24^a,**	305.16 ± 4.82^a,**
STZ+ Pet ether fraction (200 mg/kg)	284.04 ± 1.82	280.14 ± 5.76	265.16 ± 6.28^b,*	256.53 ± 6.72^b,**	248.83 ± 6.42^b,*	234.71 ± 5.67^b,**
STZ + Chloroform fraction (200 mg/kg)	267.24 ± 1.46	262.63 ± 1.45	258.84 ± 2.18	254.5 ± 2.14	253.49 ± 2.81	261.24 ± 3.81
STZ + Ethyl acetate fraction (200 mg/kg)	264.81 ± 1.96	241.16 ± 4.54	229.23 ± 6.14^b,**	212.38 ± 6.51^b,**	197.67 ± 7.68^b,**	187.28 ± 6.436^b,**
STZ + Aqueous fraction (200 mg/kg)	286.90 ± 2.31	285.09 ± 3.81	281.84 ± 2.18	279.30 ± 2.72	272.65 ± 2.73	279.50 ± 3.73
STZ + Glibenclamide (0.5 mg/kg)	286.50 ± 6.35	255.50 ± 8.08^b,**	224.83 ± 7.18^b,**	162.00 ± 7.81^b,**	162.00 ± 7.81^b,**	111.50 ± 7.13^b,**

Values are given as mean ± SEM, 6 rats in each group,
^a,∗∗𝑃<0.001 as compared to normal control group,
^b,∗𝑃<0.05, ^∗∗𝑃<0.001, when compared with STZ-treated control group.