Effect of Potent Ethyl Acetate Fraction of Stereospermum suaveolens Extract in Streptozotocin-Induced Diabetic Rats

Table 4

Effect of ethyl acetate fraction of Stereospermum suaveolens on pancreatic lipid peroxidation, glutathione, and antioxidants in STZ-induced diabetic rats.

Groups	Lipid peroxidation (nmol of MDA/mg protein)	Glutathione (μM/gm protein)	Superoxide dismutase (IU/mg protein)	Catalase (nmol of H2O2 decomposed/min/mg protein)	Liver glycogen (mg/gm of liver)
Normal (5% DMSO in 0.9% NaCl, 5 mL/kg)	11.13±0.56	49.28±1.26	26.42±0.68	56.26±1.82	35.20±0.89
STZ-induced diabetic control (40 mg/kg)	35.46±0.43^a,#	23.58±1.79^a,#	9.63±0.67^a,#	28.45±1.48^a,#	12.31±0.63^a,#
STZ + Ethyl acetate fraction (200 mg/kg)	14.37±0.56^b, **	44.38±1.24^b, **	20.31±0.42^b,**	51.72±1.26^b, **	29.84±0.49^b,*
STZ + Glibenclamide (0.5 mg/kg)	22.24±0.62	37.56±1.36	16.46±0.67	43.21±1.42	24.42±1.40^b,*

Values are mean ± SEM, 6 rats in each group,
^a,#𝑃<0.001 as compared to normal control group,
^b,∗𝑃<0.05, ^∗∗𝑃<0.001, when compared with STZ-treated control group.