471417.fig.001
Figure 1: Metabolic pathway of butyrate production in Clostridia [19, 34, 35], 1: EMP pathway, 2: pyruvate-ferredoxin oxidoreductase, 3: acetyl CoA-acetyl transferase (thiolase), 4: β-hydroxy butyryl CoA dehydrogenase, 5: crotonase, 6: butyryl CoA dehydrogenase, 7: phosphotransbutyrylase, 8: butyrate kinase, 9: butyraldehyde deydrogenase, 10: butanol dehydrogenase, 11: phosphotransacetylase, 12: acetate kinase, 13: acetaldehyde dehydrogenase, 14: ethanol dehydrogenase, 15: CoA transferase, 16: acetoacetate decarboxylase, 17: ferredoxin-NAD(P)+ reductase, 18: hydrogenase, 19: butyryl CoA-acetate transferase (proposed enzyme), 20: lactate dehydrogenase.