Blood-Brain Barrier Abnormalities Caused by HIV-1 gp120: Mechanistic and Therapeutic Implications

Figure 6

NMDAR-1 activation plays a role in gp120-induced BBB injury. The potential involvement of NMDA in the BBB disturbances induced by gp120 was studied using memantine, a NMDA receptor antagonist. Injection of memantine (30 mg/kg) before (i.v.) injecting EB, followed by intra-CP gp120, limited the extent of the EB-positive area.