Genetics and Epigenetics of Parkinson's Disease

Table 1

Loci and genes associated with familial PD.

Designation	Locus	Gene	Inheritance*	Refs
Validated loci
PARK1/PARK4	4q21	SNCA	AD	[5–16]
PARK8	12q12	LRRK2	AD
PARK2	6q25.2–q27	PARK	AR
PARK6	1p35-36	PINK1	AR
PARK7	1p36	DJ-1	AR
PARK9	1p36	ATP13A2	AR
Other loci
PARK3	2p13	Unknown	AD	[17–23]
PARK5	4p14	UCH-L1	AD
PARK8	12q12	LRRK2	AD
PARK10	1p32	Unknown	Not clear
PARK11	2q36-37	GIGYF2	AD
PARK12	Xq21-q25	Unknown	X-linked
PARK13	2p12	OMI/; HTRA2	AD
PARK 14	22q13.1	PLA2G6	AR
PARK 15	22q11.2-qter	FBXO7	AR

*AD: autosomal dominant; AR: autosomal recessive.