The Scientific World Journal

Research Article

Study of the Activity of 3-benzyl-5-(4-chloro-arylazo)-4-thioxo-imidazolidin-2-one against Schistosomiasis Mansoni in Mice

Table 1

Effect of different formulations of LPSF-PT05 on worm burdens and oogram patterns in experimentally infected mice harbouring adult S. mansoni (BH strain).
Group Dosing protocols (mg/Kg × day) Worm reductions% egg developmental stages
Total wormsTotal worms reduction%Total ImmatureMatureDead
Control (7) 2 4 . 6 0 ± 1 6 . 2 9 — 5 8 . 8 8 ± 1 4 . 1 9 2 7 . 8 0 ± 1 0 . 1 8 1 3 . 3 3 ± 4 . 4 0
LPSF-PT05-Tween (7)100 × 5 1 9 . 4 3 ± 7 . 8 7 21.0 4 7 . 5 0 ± 7 . 3 7 2 7 . 9 3 ± 5 . 4 9 2 4 . 5 8 ± 7 . 9 7
Control (5) 3 0 . 4 3 ± 1 2 . 2 0 5 0 . 7 2 ± 6 . 1 4 2 9 . 5 2 ± 4 . 1 6 1 9 . 7 1 ± 5 . 5 1
LPSF-PT05-Emulsion (5)100 × 5 1 8 . 2 5 ± 2 . 8 7 40.0 3 6 . 1 0 ± 1 2 . 6 8 3 1 . 6 7 ± 4 . 3 5 3 2 . 2 3 ± 1 4 . 5 7
Control (5) 2 6 . 5 0 ± 1 2 . 3 4 5 7 . 5 1 ± 1 . 1 7 3 4 . 1 6 ± 3 . 5 3 8 . 3 3 0 ± 2 . 3 6
LPSF-PT05-PEG (5)100 × 5 7 . 8 0 ± 3 . 2 7 70.5# 3 5 . 3 4 ± 7 . 0 5 * 4 1 . 4 1 ± 3 . 4 8 2 3 . 2 5 ± 5 . 0 1 #
30 × 5 1 4 . 0 0 ± 2 . 0 8 47.1# 4 9 . 1 7 ± 6 . 0 6 2 4 . 3 8 ± 4 . 8 7 2 6 . 4 6 ± 4 . 6 6 #
10 × 5 1 3 . 8 0 ± 4 . 4 3 47.9# 4 0 . 5 9 ± 1 5 . 4 6 3 3 . 3 3 ± 1 2 . 0 2 2 6 . 1 0 ± 3 . 4 8 #
3 × 5 2 1 . 2 5 ± 3 . 4 0 19.8 5 3 . 7 6 ± 5 . 9 9 2 8 . 3 3 ± 3 . 6 0 1 6 . 6 6 ± 2 . 3 5
The values are expressed in means ± SD. * 𝑃 ≤ 0 . 0 5 , # 𝑃 ≤ 0 . 0 1 in comparison to control.
Numbers in brackets represent the numbers of mice.