Sorafenib Inhibits Tumor Growth and Improves Survival in a Transgenic Mouse Model of Pancreatic Islet Cell Tumors
Figure 3
Effects of Sorafenib in the early treatment group on tumor size (measured by the tumor area in μm2) and on pancreas weight (mg) of Rip1Tag2 mice assessed by manual measurement. (a) Boxplot for the islet cell area; (b) Boxplot for the pancreas weight (mg). (c) Treatment with Sorafenib significantly augmented apoptosis and inhibited proliferation. (c (c1 and c2)) Boxplots showing percentage (%) of caspase-3 positive and BrdU positive cells in mice from the early treatment group induced by Sorafenib. (c (c3)) Treatment with Sorafenib significantly increased VEGF-expression. VEGF-expression in Sorafenib treated and control mice assessed by RT-PCR.
