Table 1: Risk factors and clinical characteristics of stroke patients with and without leukoaraiosis.

No LeukoaraiosisLeukoaraiosis
Index( 𝑛 = 9 8 )( 𝑛 = 7 2 ) 𝑃 -value

Age, years62.6 ± 13.771.4 ± 11.3<0.001
Male gender, %62.059.70.770
BMI, kg/m227 ± 4.526.8 ± 4.50.700
Diabetes mellitus, %22.436.10.051
Hypertension, %54.174.60.006
Hyperlipidemia, %45.947.90.800
Current smoker, %29.821.40.230
Ever smoker, %56.853.50.670
Mean IMT*, mm0.81 ± 1.120.86 ± 1.130.002
Median IMT, (IQR), mm0.60 (0.55–0.74)0.70 (0.6–0.84)0.002
Carotid plaque/s, %63.382.60.007

NIHSS3.9 ± 4.44.3 ± 3.40.580

             Medication use

Acetylsalicylic acid, %33.750.00.032
Clopidogrel, %1.06.90.039
Beta Blockers, %21.433.30.082
Calcium blockers, %14.329.20.018
ACE Inhibitors, %30.645.80.042
ARBs, %1.04.20.181
HMG-CoA reductaseinhibitors, %21.625.00.609
Within lacunar strokes, %50.050.00.121

BMI indicates body mass index; IMT: intima-media thickness; NIHSS: National Institutes of Health Stroke Scale; ACE: angiotensin converting enzyme; ARB: angiotensin receptor blockers; HMG-CoA, 3-hydroxy-3-methylglutaryl-Coenzyme A.
*Data were logarithmically transformed before analysis, presented is the geometric mean (SD).