PHBV/PCL Microparticles for Controlled Release of Resveratrol: Physicochemical Characterization, Antioxidant Potential, and Effect on Hemolysis of Human Erythrocytes

Table 2

Mathematical models related to dissolution experiments.

Model	Equation
Dissolution efficiency	DE=(∫^𝑡0𝑦⋅𝑑𝑡/𝑦100⋅𝑡)×100%
First-order	%𝐷=100(1−𝑒^−𝑘𝑡)
Biexponential	%𝐷=100[1−(𝐴𝑒^−𝛼𝑡+𝐵𝑒^−𝛽𝑡)]
Zero-order	%𝐷=𝑘𝑡
Weibull	%𝐷=100[1−𝑒^−(𝑡/𝑇𝐷)𝑏]

Legend: %𝐷: dissolved percentage, 𝑏: shape parameter, 𝑇𝐷: time interval necessary to release 63.2% of the drug, k, α and β: kinetics constants, 𝑡: dissolution time, 𝐴 and 𝐵: initial drug concentrations that contribute for the two dissolution stages.