Striatal Input- and Rate-Dependent Effects of Muscarinic Receptors on Pallidal Firing

Figure 1

Intrapallidal activation of MRs produces heterogeneous effects on the baseline firing rate of globus pallidus neurons recorded in normal rats. (a) Bethanechol 100 pmol, 1 and 10 nmol increases the spiking rate in a dose-dependent manner (*𝑃<0.05 as compared to bethanechol 100 pmol and 1 nmol. One-way ANOVA, Newman-Keuls post-hoc test). (b) Frequency histogram showing the increase in baseline firing rate induced by local application of 1 nmol bethanechol. (c) In another group of globus pallidus neurons, bethanechol decreases the spiking rate in a dose-dependent manner. (*𝑃<0.01, as compared to 100 pmol bethanechol, one-way ANOVA, Newman-Keuls post-hoc test). (d) Frequency histogram illustrating the inhibitory effect of 1 nmol bethanechol on a pallidal neuron. spks/s, spikes per second.

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