Striatal Input- and Rate-Dependent Effects of Muscarinic Receptors on Pallidal Firing
Figure 2
The effect of local activation of MRs depends on the firing rate before the application of different doses of bethanechol. (a) Shows that bethanechol 1 nmol produces heterogeneous effects on the spiking rate of globus pallidus neurons depending on the baseline firing rate before drug application. Only data from six neurons that suffered excitation are plotted. (b) Statistics showing that the excitation or inhibition evoked by 1 and 10 nmol bethanechol depends on the predrug baseline firing rate. *; t-test. spks/s, spikes per second.
