Striatal Input- and Rate-Dependent Effects of Muscarinic Receptors on Pallidal Firing
Figure 4
The increase in the tonic cholinergic input modifies the firing rate in globus pallidus neurons depending on the baseline firing rate before application of tacrine. (a) Frequency histogram showing the firing rate inhibition induced by local application of 5 nmol tacrine in a globus pallidus neuron firing at ~75 spikes/s. (b) Statistics illustrating that the effect of the local blockade of acetylcholinesterase in the spiking rate depends on the baseline firing rate before local infusion of 5 nmol tacrine (*; t-test). spks/s, spikes per second; NE/Excited, no effect or excitation.
