Striatal Input- and Rate-Dependent Effects of Muscarinic Receptors on Pallidal Firing

Figure 5

The activation of MRs in the globus pallidus has differential characteristics between sham and ipsilateral striatum-lesioned rats. (a) Intraperitoneal application of apomorphine (0.5 mg/kg) induces ipsilateral turning behavior in rats with striatal lesion. (*𝑃<0.01; & 𝑃<0.05, t-test). (b) In sham rats, the predrug (1 nmol bethanechol) baseline firing rate was higher in neurons that were inhibited by bethanecol than the baseline firing rate recorded in neurons from lesioned rats that were also inhibited by the same concentration of bethanechol (*𝑃<0.029, t-test). (c) The percent of inhibition evoked by 1 nmol bethanechol is higher in neurons recorded in sham rats than in those recorded in lesioned rats (*𝑃<0.04, t-test). APP, application time (down arrow); spks/s, spikes per second.

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