Effect of a Novel Nonviral Gene Delivery of BMP-2 on Bone Healing

Table 2

Histomorphometric analysis of the tibial callus region after 28 and 42 days. There was significantly less mineralized area in the periosteal callus area in the COPROG + BMP-2 group compared to the control group at day 28 and no difference in the other parameters between the groups at both time points.

	28 days			42 days
	Control	Copolymer	COPROG + BMP	Control	Copolymer	COPROG + BMP
Mineralized Ar./Co.Ar (%)	97.9 ± 1.32	97.4 ± 0.97	95.4 ± 1.49	97.2 ± 0.87	97.2 ± 0.92	97.1 ± 1.19
Periosteal Cl.Ar (Ti.Dm) (mm)	5.0 ± 0.88	5.2 ± 0.93	5.5 ± 1.86	5.0 ± 1.26	6.4 ± 1.78	6.8 ± 2.38
Mineralized Ar./Ps.Cl.Ar (%)	77.9 ± 6.36	71.4 ± 6.39	64.0 ± 11.18^1	79.4 ± 9.28	73.9 ± 9.31	71.0 ± 11.64
Cartilage Ar./Ps.Cl.Ar (%)	5.3 ± 4.18	9.6 ± 5.21	5.1 ± 3.59	6.0 ± 4.54	6.3 ± 3.34	5.3 ± 4.65

𝑃<0.05 (ANOVA, Bonferroni).
¹Significant difference to Control group at the same time point.