Table 2: Histomorphometric analysis of the tibial callus region after 28 and 42 days. There was significantly less mineralized area in the periosteal callus area in the COPROG + BMP-2 group compared to the control group at day 28 and no difference in the other parameters between the groups at both time points.

28 days42 days
ControlCopolymerCOPROG + BMPControlCopolymerCOPROG + BMP

Mineralized Ar./Co.Ar (%)97.9 ± 1.3297.4 ± 0.9795.4 ± 1.4997.2 ± 0.8797.2 ± 0.9297.1 ± 1.19
Periosteal Cl.Ar (Ti.Dm) (mm)5.0 ± 0.885.2 ± 0.935.5 ± 1.865.0 ± 1.266.4 ± 1.786.8 ± 2.38
Mineralized Ar./Ps.Cl.Ar (%)77.9 ± 6.3671.4 ± 6.3964.0 ± 11.18179.4 ± 9.2873.9 ± 9.3171.0 ± 11.64
Cartilage Ar./Ps.Cl.Ar (%)5.3 ± 4.189.6 ± 5.215.1 ± 3.596.0 ± 4.546.3 ± 3.345.3 ± 4.65

(ANOVA, Bonferroni).
1Significant difference to Control group at the same time point.