The Scientific World Journal

Research Article

Assessing the Risk of Birth Defects Associated with Exposure to Fixed-Dose Combined Antituberculous Agents during Pregnancy in Rats

Table 3

Gross pathological (morphology) results of fetuses of treated animals.
GroupsStage of exposureNo. of foetus useFormation of digital raysNeural tube defectCleft palateGeneral growth abnormalitiesAbnormal heartAbnormal liverAbnormal brainAbnormal kidney
Group 1ORG180/180/180/180/180/180/180/180/18
Group 2ORG180/180/180/180/180/180/180/180/18
Group 3ORG180/180/180/182/180/180/180/180/18
ORG: organogenesis.
Group 1: control group. Group 2: administered with clinical dose (51.4 mg/kg/day) of fixed-dose combined antituberculous agents. Group 3: administered with clinical dose of fixed-dose combined antituberculous agents plus 10 mg/kg/day of Vitamin C.