Assessing the Risk of Birth Defects Associated with Exposure to Fixed-Dose Combined Antituberculous Agents during Pregnancy in Rats
Table 4
Hematological Profile of Rats at first filial.
Groups
SOE
NOF
WBC (Mean ± SEM)
RBC (Mean ± SEM)
HGB (Mean ± SEM)
HCT (Mean ± SEM)
PCT (Mean ± SEM)
LYPM (Mean ± SEM)
NEU (Mean ± SEM)
Group 1
ORG
6
Group 2
ORG
6
Group 3
ORG
6
SOE: stage of exposure, NOF: number of animals, ORG: organogenesis, WBC: white blood cell count, RBC: red blood cell count, HGB: hemoglobin count, HCT: haematocrit, PCT: platelet count, LYPM: lymphocyte, NEU: neutrophiles. compared with group 1 (control). Group 1: control group. Group 2: administered with clinical dose (51.4 mg/kg/day) of fixed-dose combined antituberculous agents. Group 3: administered with clinical dose of fixed-dose combined antituberculous agents plus 10 mg/kg/day of Vitamin C.