Research Article

Assessing the Risk of Birth Defects Associated with Exposure to Fixed-Dose Combined Antituberculous Agents during Pregnancy in Rats

Table 5

Blood chemistry Results at first filial.

GroupsSOE š‘ AST (Meanā€‰Ā±ā€‰SEM)CREA (Meanā€‰Ā± SEM)ALT (Meanā€‰Ā±ā€‰SEM)UREA (Meanā€‰Ā± SEM)T. PRO (Meanā€‰Ā± SEM)CHOLES (Meanā€‰Ā± SEM)TG (Meanā€‰Ā±ā€‰SEM)ALP (Meanā€‰Ā±ā€‰SEM)

Group 1ORG6 1 5 1 . 3 Ā± 1 2 . 2 5 3 8 . 0 2 Ā± 1 . 2 8 5 7 1 . 3 0 Ā± 7 . 4 3 3 4 . 8 7 3 Ā± 0 . 2 8 0 7 2 . 1 7 Ā± 1 . 4 9 7 2 . 2 1 7 Ā± 0 . 0 7 9 0 . 8 1 6 7 Ā± 0 . 0 4 8 1 7 1 . 9 Ā± 3 . 6 5
Group 2ORG6 2 1 3 . 3 Ā± 1 6 . 3 5 āˆ— 3 3 . 1 2 Ā± 1 . 2 8 5 5 7 . 7 8 Ā± 4 . 8 9 8 . 7 3 Ā± 1 . 7 4 6 āˆ— 6 5 . 8 8 Ā± 2 . 1 8 āˆ— 2 . 0 3 Ā± 0 . 2 7 0 . 5 0 Ā± 0 . 0 3 7 āˆ— 2 1 1 . 6 Ā± 1 2 . 9 āˆ—
Group 3ORG6 1 6 3 . 6 Ā± 1 6 . 0 9 š›¼ 2 3 . 8 6 Ā± 2 . 3 1 5 3 . 0 3 Ā± 1 2 . 3 9 8 . 9 5 0 Ā± 0 . 2 9 5 āˆ— 4 9 . 3 0 Ā± 1 . 3 9 š›¼ 2 . 0 5 2 Ā± 0 . 1 1 0 . 8 6 Ā± 0 . 0 5 1 2 8 7 Ā± 5 5 . 3 š›¼

SOE: stage of exposure, ORG: organogenesis, N: number of animals, AST: aspartate aminotransferase, CREA: creatinine, ALT: alanine aminotransferase, T.PRO: total protein, CHOLES: cholesterol, TG: triglyceride, ALP: alkaline phosphatase.
āˆ— š‘ƒ ā‰¤ 0 . 0 5 compared with group 1 (control).
š›¼ š‘ƒ ā‰¤ 0 . 0 5 compared with group 2.
Group 1: control group. Group 2: administered with clinical dose (51.4ā€‰mg/kg/day) of fixed-dose combined antituberculous agents. Group 3: administered with clinical dose of fixed-dose combined antituberculous agents plus 10ā€‰mg/kg/day of Vitamin C.