Assessing the Risk of Birth Defects Associated with Exposure to Fixed-Dose Combined Antituberculous Agents during Pregnancy in Rats
Table 5
Blood chemistry Results at first filial.
Groups
SOE
AST (MeanāĀ±āSEM)
CREA (MeanāĀ± SEM)
ALT (MeanāĀ±āSEM)
UREA (MeanāĀ± SEM)
T. PRO (MeanāĀ± SEM)
CHOLES (MeanāĀ± SEM)
TG (MeanāĀ±āSEM)
ALP (MeanāĀ±āSEM)
Group 1
ORG
6
Group 2
ORG
6
Group 3
ORG
6
SOE: stage of exposure, ORG: organogenesis, N: number of animals, AST: aspartate aminotransferase, CREA: creatinine, ALT: alanine aminotransferase, T.PRO: total protein, CHOLES: cholesterol, TG: triglyceride, ALP: alkaline phosphatase. compared with group 1 (control). compared with group 2. Group 1: control group. Group 2: administered with clinical dose (51.4āmg/kg/day) of fixed-dose combined antituberculous agents. Group 3: administered with clinical dose of fixed-dose combined antituberculous agents plus 10āmg/kg/day of Vitamin C.