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The Scientific World Journal
Volume 2012 (2012), Article ID 598653, 5 pages
http://dx.doi.org/10.1100/2012/598653
Research Article

Does Thrombocyte Size Give Us an Idea about Thrombocytosis Etiology?

1Department of Hematology, Faculty of Medicine, Baskent University, 06490 Ankara, Turkey
2Department of Biostatistics, Faculty of Medicine, Ankara University, 06100 Ankara, Turkey
3Hematology Laboratory, Faculty of Medicine, Baskent University, 06490 Ankara, Turkey
4Department of Plastic, Reconstructive and Aesthetic Surgery, Ankara Training and Research Hospital, 06080 Ankara, Turkey

Received 4 July 2012; Accepted 22 August 2012

Academic Editors: A. Guerrasio and I. Lorand-Metze

Copyright © 2012 Selami Kocak Toprak et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

In the presence of a pathogenetic mutation in JAK2 or MPL, a differential diagnosis of essential thrombocythemia (ET) from reactive causes is relatively simple. However, in patients with suspected ET who lack JAK2 and MPL mutations, the exclusion of secondary causes is especially important. The study was aimed to explore the clinical application of particularly mean platelet volume (MPV), hemoglobin, red blood cell indices, white blood cell, serum iron profile, and C-reactive protein level in the differential diagnosis of thrombocytosis. Medical records of 49 patients, consisting of reactive thrombocytosis (RT) and ET were retrospectively reviewed. The mean MPV level in RT group was 7.49 fL, and in ET group was 8.80 fL ( 𝑃 < 0 . 0 1 ). A cutoff point of <8.33 fL was found to have significant predictive value according to ROC curve analysis. This cutoff was associated with 83% positive predictive value (PPV) and 74% negative predictive value (NPV) in the diagnosis of ET and had a sensitivity of 65% and specificity of 89% for ET. Investigation of MPV is cheap, quick, and noninvasive, and may serve as a predictor of primary thrombocytosis. High sensitivity, specificity, PPV, and NPV enable this test an important tool and a possible surrogate marker in clinical practice.