Research Article
Robust Optimization of Alginate-Carbopol 940 Bead Formulations
Table 2
Factors and their corresponding levels implemented for the construction of orthogonal array.
| Factor | Levels used, actual (coded) | Low (−1) | Medium (0) | High (+1) |
| Independent variables | | | | A: addition of TEA | No | | Yes | B: concentration of Carbopol (% w/v) | 1 | 2 | 4 | C: flux rate of polymeric solution (mL/min) | 1 | 2 | 3 | D: stirring rate of stirrer (rpm) | 100 | 300 | 500 | E: reaction time of beads into CaCl2 solution (min) | 5 | 30 | 60 | F: drying method | Room | Rotary evaporator | Oven | G: NaCl (% w/v) | 0 | 0.01 | 0.1 | H: pH | 7.2 | 7.6 | 8.0 |
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