Robust Optimization of Alginate-Carbopol 940 Bead Formulations

Table 4

Experimental layout using a 𝐿₁₈ orthogonal array and results obtained in every run.

Run		𝑡50%		AUC		EE		SR		SF		Dm
		Mean	𝑆/𝑁	Mean	𝑆/𝑁	Mean	𝑆/𝑁	Mean	𝑆/𝑁	Mean	𝑆/𝑁	Mean	𝑆/𝑁
1	𝐴−1𝐵−1𝐶−1𝐷−1	73.00	28.82	268.68	49.11	48.43	37.04	2863.78	69.14	0.52	−5.74	1.34	−2.71
	𝐸−1𝐹−1𝐺−1𝐻−1
2	𝐴−1𝐵−1𝐶𝑜𝐷𝑜	50.00	27.96	421.78	49.29	54.88	38.26	1937.37	65.74	0.20	−13.88	1.47	−3.43
	𝐸𝑜𝐹𝑜𝐺𝑜𝐻0
3	𝐴−1𝐵−1𝐶1𝐷1	69.33	35.57	117.23	48.60	53.63	38.08	1320.67	62.42	0.25	−12.06	1.53	−3.70
	𝐸1𝐹1𝐺1𝐻1
4	𝐴−1𝐵𝑜𝐶−1𝐷−1	91.33	31.94	461.89	48.23	54.88	38.17	1681.62	64.51	0.58	−4.77	1.72	−2.96
	𝐸𝑜𝐹𝑜𝐺1𝐻1
5	𝐴−1𝐵𝑜𝐶𝑜𝐷𝑜	102.33	32.18	405.74	48.66	59.00	38.92	2177.52	66.76	0.27	−11.32	1.64	−4.50
	𝐸1𝐹1𝐺−1𝐻−1
6	𝐴−1𝐵𝑜𝐶1𝐷1	198.33	25.60	348.62	47.04	53.51	38.08	1119.52	60.98	0.65	−3.83	1.69	−4.61
	𝐸−1𝐹−1𝐺𝑜𝐻0
7	𝐴−1𝐵1𝐶−1𝐷𝑜	118.67	19.17	354.48	48.22	54.34	38.21	1610.31	64.14	0.30	−10.47	1.51	−3.65
	𝐸−1𝐹1𝐺𝑜𝐻1
8	𝐴−1𝐵1𝐶𝑜𝐷1	293.33	28.10	257.57	46.46	54.46	38.24	1082.83	60.69	0.25	−12.01	1.54	−3.73
	𝐸𝑜𝐹−1𝐺1𝐻−1
9	𝐴−1𝐵1𝐶1𝐷−1	106.00	18.80	427.85	47.90	57.14	38.65	1459.06	63.28	0.55	−5.26	1.66	−4.42
	𝐸1𝐹𝑜𝐺−1𝐻0
10	𝐴1𝐵−1𝐶−1𝐷1	60.00	24.77	448.50	48.89	59.73	39.04	2786.18	68.90	0.19	−14.68	2.07	−6.33
	𝐸1𝐹𝑜𝐺𝑜𝐻−1
11	𝐴1𝐵−1𝐶𝑜𝐷−1	82.67	22.18	634.32	48.71	59.33	38.97	1151.14	61.22	0.26	−11.95	1.83	−5.27
	𝐸−1𝐹1𝐺1𝐻0
12	𝐴1𝐵−1𝐶1𝐷𝑜	119.33	40.29	401.70	47.93	56.07	38.49	3685.23	71.32	0.55	−5.20	1.57	−3.97
	𝐸𝑜𝐹−1𝐺−1𝐻1
13	𝐴1𝐵𝑜𝐶−1𝐷𝑜	111.67	23.30	1326.03	47.92	58.83	38.91	1868.79	65.39	0.40	−9.30	1.73	−5.12
	𝐸1𝐹−1𝐺1𝐻0
14	𝐴1𝐵𝑜𝐶𝑜𝐷1	148.67	36.17	225.15	47.45	59.88	39.06	3003.21	69.55	0.20	−13.88	1.72	−4.70
	𝐸−1𝐹𝑜𝐺−1𝐻1
15	𝐴1𝐵𝑜𝐶1𝐷−1	209.33	36.72	469.47	47.14	59.49	39.00	2017.31	66.10	0.38	−8.50	1.56	−4.01
	𝐸𝑜𝐹1𝐺𝑜𝐻−1
16	A1B1C−1D1	238.67	40.29	1052.68	46.04	53.97	38.15	3094.41	69.81	0.35	−9.26	1.67	−4.54
	𝐸𝑜𝐹1𝐺−1𝐻0
17	𝐴1𝐵1𝐶𝑜𝐷−1	142.00	32.25	536.70	48.08	56.39	38.52	1554.57	63.83	0.34	−9.40	1.41	−3.04
	𝐸1𝐹−1𝐺𝑜𝐻1
18	𝐴1𝐵1𝐶1𝐷𝑜	138.33	33.61	841.84	47.79	60.02	39.08	1420.16	63.05	0.26	−11.71	2.81	−8.99
	𝐸−1𝐹𝑜𝐺1𝐻−1