NOD2 Agonist Promotes the Production of Inflammatory Cytokines in VSMC in Synergy with TLR2 and TLR4 Agonists

Figure 1

MDP induced the expression of NOD2 in VSMC. MDP stimulation (10 ng/mL) caused time-dependent increase of NOD2 mRNA expression in VSMC and reached a peak at 24 h (0 h: 0.028 ± 0.001, 3 h: 0.045 ± 0.002; 6 h: 0.053 ± 0.002; 24 h: 0.162 ± 0.013; ^∗𝑃<0.05, ^∗∗𝑃<0.01, 𝑛=3). NOD2 mRNA relative expression level = NOD2/cyclophilin A.