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The Scientific World Journal
Volume 2012 (2012), Article ID 615068, 10 pages
http://dx.doi.org/10.1100/2012/615068
Clinical Study

Human Elimination of Phthalate Compounds: Blood, Urine, and Sweat (BUS) Study

1Faculty of Medicine, University of Alberta, 2935-66 Street, Edmonton, AB, Canada T6K 4C1
2Department of Laboratory Medicine, University of Alberta, Edmonton, AB, Canada T6G 2B7
3Department of Family Medicine, University of Alberta, Edmonton, AB, Canada T6G 2C8
4Environmental Division, A.L.S. Laboratory Group, Edmonton, AB, Canada T6E 5C1

Received 21 July 2012; Accepted 3 October 2012

Academic Editors: A. Basu, W. Gelderblom, J. B. T. Rocha, and E. Shibata

Copyright © 2012 Stephen J. Genuis et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Individual members of the phthalate family of chemical compounds are components of innumerable everyday consumer products, resulting in a high exposure scenario for some individuals and population groups. Multiple epidemiological studies have demonstrated statistically significant exposure-disease relationships involving phthalates and toxicological studies have shown estrogenic effects in vitro. Data is lacking in the medical literature, however, on effective means to facilitate phthalate excretion. Methods. Blood, urine, and sweat were collected from 20 individuals (10 healthy participants and 10 participants with assorted health problems) and analyzed for parent phthalate compounds as well as phthalate metabolites using high performance liquid chromatography-tandem mass spectrometry. Results. Some parent phthalates as well as their metabolites were excreted into sweat. All patients had MEHP (mono(2-ethylhexyl) phthalate) in their blood, sweat, and urine samples, suggesting widespread phthalate exposure. In several individuals, DEHP (di (2-ethylhexl) phthalate) was found in sweat but not in serum, suggesting the possibility of phthalate retention and bioaccumulation. On average, MEHP concentration in sweat was more than twice as high as urine levels. Conclusions. Induced perspiration may be useful to facilitate elimination of some potentially toxic phthalate compounds including DEHP and MEHP. Sweat analysis may be helpful in establishing the existence of accrued DEHP in the human body.