Review Article
Neurobiology, Pathophysiology, and Treatment of Melatonin Deficiency and Dysfunction
Table 1
Diseases and disorders that cause decreases in human* melatonin secretion independently of apparent tissue destruction in SCN or pineal gland.
| Disease/disorder | Comments | References |
| Schizophrenia | Only in a subpopulation | [57, 58] | Multiple sclerosis with major depression | In major depression alone, mostly phase shifts instead of decreases | [59–62] | Primary obsessive-compulsive disorder | | [63] | Menière’s disease | Relationship to stress by tinnitus and vertigo? | [64] | Fibromyalgia | Studied in women | [65–67] | | Pain reduced by melatonin | [67–69] | Migraine | | [70, 71] | Critical illness | | [72–74] | Endometrial cancer | | [75] | Nonsmall cell lung cancer | In part caused by pain? | [76] | Acute intermittent porphyria | Further decreased by seizures | [77, 78] | Diabetes type 2 | | [79, 80] |
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*For preclinical findings of these and other diseases or respective animal models see [3].
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