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The Scientific World Journal
Volume 2012 (2012), Article ID 671728, 8 pages
http://dx.doi.org/10.1100/2012/671728
Research Article

Low-Dose Fluvastatin Prevents the Functional Alterations of Endothelium Induced by Short-Term Cholesterol Feeding in Rabbit Carotid Artery

1Department of Pharmacology, Faculty of Pharmacy, Ege University, Bornova, 35100 Izmir, Turkey
2Department of Biochemistry, Faculty of Medicine, Ege University, 35100 Izmir, Turkey

Received 11 October 2011; Accepted 16 November 2011

Academic Editors: J. Sastre and E. Skalidis

Copyright © 2012 Gulnur Sevin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. U. Forstermann and T. Munzel, “Endothelial nitric oxide synthase in vascular disease: from marvel to menace,” Circulation, vol. 113, no. 13, pp. 1708–1714, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  2. K. G. Reddy, R. N. Nair, H. M. Sheehan, and M. J. Hodgson, “Evidence that selective endothelial dysfunction may occur in the absence of angiographic or ultrasound atherosclerosis in patients with risk factors for atherosclerosis,” Journal of the American College of Cardiology, vol. 23, no. 4, pp. 833–843, 1994. View at Scopus
  3. P. M. Vanhoutte, “Endothelial dysfunction: the first step toward coronary arteriosclerosis,” Circulation Journal, vol. 73, no. 4, pp. 595–601, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. S. Parthasarathy, N. Santanam, S. Ramachandran, and O. Meilhac, “Invited review: potential role of oxidized lipids and lipoproteins in antioxidant defense,” Free Radical Research, vol. 33, no. 3, pp. 197–215, 2000. View at Scopus
  5. J. Sastre, F. V. Pallardo, J. Garcia de La Asunción, and J. Vina, “Mitochondria, oxidative stress and aging,” Free Radical Research, vol. 32, no. 3, pp. 189–198, 2000.
  6. G. Ambrosio and I. Tritto, “Reperfusion injury: experimental evidence and clinical implications,” American Heart Journal, vol. 138, no. 2, pp. S69–S75, 1999. View at Publisher · View at Google Scholar · View at Scopus
  7. S. L. Pfister and W. B. Campbell, “Contribution of arachidonic acid metabolites to reduced norepinephrine-induced contractions in hypercholesterolemic rabbit aortas,” Journal of Cardiovascular Pharmacology, vol. 28, no. 6, pp. 784–791, 1996. View at Scopus
  8. D. A. Cox and M. L. Cohen, “Selective enhancement of 5-hydroxytryptamine-induced contraction of porcine coronary artery by oxidized low-density lipoprotein,” Journal of Pharmacology and Experimental Therapeutics, vol. 276, no. 3, pp. 1095–1103, 1996. View at Scopus
  9. C. Rodriguez, J. F. Alcudia, J. Martinez-Gonzalez et al., “Statins normalize vascular lysyl oxidase down-regulation induced by proatherogenic risk factors,” Cardiovascular Research, vol. 83, no. 3, pp. 595–603, 2009. View at Publisher · View at Google Scholar · View at PubMed
  10. M. Ii and D. W. Losordo, “Statins and the endothelium,” Vascular Pharmacology, vol. 46, no. 1, pp. 1–9, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  11. H. Mitani, K. Egashira, N. Ohashi et al., “Preservation of endothelial function by the HMG-CoA reductase inhibitor fluvastatin through its lipid-lowering independent antioxidant properties in atherosclerotic rabbits,” Pharmacology, vol. 68, no. 3, pp. 121–130, 2003. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  12. Y. D. Akcay, A. Yalcin, and E. Y. Sozmen, “The effect of melatonin on lipid peroxidation and nitrite/nitrate levels, and on superoxide dismutase and catalase activities in kainic acid-induced injury,” Cellular and Molecular Biology Letters, vol. 10, no. 2, pp. 321–329, 2005. View at Scopus
  13. O. H. Lowry, N. J. Rosebrough, A. L. Farr, and R. J. Randall, “Protein measurement with the Folin phenol reagent,” The Journal of Biological Chemistry, vol. 193, no. 1, pp. 265–275, 1951. View at Scopus
  14. E. Y. Sozmen, Z. Kerry, F. Uysal et al., “Antioxidant enzyme activities and total nitrite/nitrate levels in the collar model. Effect of nicardipine,” Clinical Chemistry and Laboratory Medicine, vol. 38, no. 1, pp. 21–25, 2000. View at Scopus
  15. P. N. Bories and C. Bories, “Nitrate determination in biological fluids by an enzymatic one-step assay with nitrate reductase,” Clinical Chemistry, vol. 41, no. 6, pp. 904–907, 1995. View at Scopus
  16. M. Yasa, Z. Kerry, B. Reel, G. Yetik Anacak, E. Ertuna, and A. Ozer, “The effects of calcium channel blockers are not related to their chemical structure in the collar model of the rabbit,” Journal of International Medical Research, vol. 35, no. 1, pp. 59–71, 2007. View at Scopus
  17. F. J. Miranda, J. A. Alabadí, S. Llorens, R. F. Ruiz de Apodaca, J. M. Centeno, and E. Alborch, “Influence of experimental diabetes on regulatory mechanisms of vascular response of rabbit carotid artery to acetylcholine,” Life Sciences, vol. 66, no. 21, pp. 2071–2080, 2000. View at Publisher · View at Google Scholar · View at Scopus
  18. P. Dilaveris, G. Giannopoulos, M. Riga, A. Synetos, and C. Stefanadis, “Beneficial effects of statins on endothelial dysfunction and vascular stiffness,” Current Vascular Pharmacology, vol. 5, no. 3, pp. 227–237, 2007. View at Publisher · View at Google Scholar · View at Scopus
  19. B. Sadowitz, K. G. Maier, and V. Gahtan, “Basic science review: statin therapy-part I: the pleiotropic effects of statins in cardiovascular disease,” Vascular and Endovascular Surgery, vol. 44, no. 4, pp. 241–251, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  20. B. Sadowitz, K. Seymour, M. J. Costanza, and V. Gahtan, “Statin therapy-part II: clinical considerations for cardiovascular disease,” Vascular and Endovascular Surgery, vol. 44, no. 6, pp. 421–433, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  21. D. C. Schwenke, “Comparison of aorta and pulmonary artery: I. Early cholesterol accumulation and relative susceptibility to atheromatous lesions,” Circulation Research, vol. 81, no. 3, pp. 338–345, 1997. View at Scopus
  22. R. P. Brandes, A. Behra, C. Lebherz, R. H. Boger, S. M. Bode-Boger, and A. Mugge, “Lovastatin maintains nitric oxide-but not EDHF-mediated endothelium- dependent relaxation in the hypercholesterolemic rabbit carotid artery,” Atherosclerosis, vol. 142, no. 1, pp. 97–104, 1999. View at Publisher · View at Google Scholar · View at Scopus
  23. B. Tesfamariam and A. F. DeFelice, “Endothelial injury in the initiation and progression of vascular disorders,” Vascular Pharmacology, vol. 46, no. 4, pp. 229–237, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  24. D. Pratico, “Antioxidants and endothelium protection,” Atherosclerosis, vol. 181, no. 2, pp. 215–224, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  25. A. L. Stewart-Lee, L. A. Forster, J. Nourooz-Zadeh, G. A. Ferns, and E. E. Anggard, “Vitamin E protects against impairment of endothelium-mediated relaxations in cholesterol-fed rabbits,” Arteriosclerosis and Thrombosis, vol. 14, no. 3, pp. 494–499, 1994. View at Scopus
  26. C. Napoli and L. J. Ignarro, “Nitric oxide and pathogenic mechanisms involved in the development of vascular diseases,” Archives of Pharmacal Research, vol. 32, no. 8, pp. 1103–1108, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  27. U. Laufs, V. L. Fata, and J. K. Liao, “Inhibition of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase blocks hypoxia-mediated down-regulation of endothelial nitric oxide synthase,” Journal of Biological Chemistry, vol. 272, no. 50, pp. 31725–31729, 1997. View at Publisher · View at Google Scholar · View at Scopus
  28. Y. Kureishi, Z. Luo, I. Shiojima et al., “The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals,” Nature Medicine, vol. 6, no. 9, pp. 1004–1010, 2000. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  29. T. Bandoh, H. Mitani, M. Niihashi et al., “Fluvastatin suppresses atherosclerotic progression, mediated through its inhibitory effect on endothelial dysfunction, lipid peroxidation, and macrophage deposition,” Journal of Cardiovascular Pharmacology, vol. 35, no. 1, pp. 136–144, 2000. View at Publisher · View at Google Scholar · View at Scopus
  30. Y. Rikitake, S. Kawashima, S. Takeshita et al., “Anti-oxidative properties of fluvastatin, an HMG-CoA reductase inhibitor, contribute to prevention of atherosclerosis in cholesterol-fed rabbits,” Atherosclerosis, vol. 154, no. 1, pp. 87–96, 2001. View at Publisher · View at Google Scholar · View at Scopus
  31. B. Tesfamariam, “The effects of HMG-CoA reductase inhibitors on endothelial function,” American Journal of Cardiovascular Drugs, vol. 6, no. 2, pp. 115–120, 2006. View at Publisher · View at Google Scholar · View at Scopus
  32. S. Ghatta and P. Ramarao, “Increased contractile responses to 5-hydroxytryptamine and Angiotensin II in high fat diet fed rat thoracic aorta,” Lipids in Health and Disease, vol. 3, article 19, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  33. C. A. Fontes Ribeiro, L. Almeida, I. Paiva et al., “Influence of 0.1 or 0.2% cholesterol-enriched diets on the induction of atherosclerosis and aorta reactivity in vitro,” Journal of Cardiovascular Pharmacology, vol. 31, no. 5, pp. 690–699, 1998. View at Publisher · View at Google Scholar · View at Scopus
  34. S. A. Doggrell and Y. Y. Chen, “Responsiveness, affinity constants and receptor reserves for serotonin on aortae of aged normotensive and hypertensive rats,” Journal of Pharmacy and Pharmacology, vol. 53, no. 10, pp. 1403–1408, 2001. View at Publisher · View at Google Scholar · View at Scopus
  35. G. Del Boccio, D. Lapenna, E. Porreca et al., “Aortic antioxidant defence mechanisms: time-related changes in cholesterol-fed rabbits,” Atherosclerosis, vol. 81, no. 2, pp. 127–135, 1990. View at Scopus
  36. S. V. Mantha, M. Prasad, J. Kalra, and K. Prasad, “Antioxidant enzymes in hypercholesterolemia and effects of vitamin E in rabbits,” Atherosclerosis, vol. 101, no. 2, pp. 135–144, 1993. View at Scopus
  37. S. V. Mantha, J. Kalra, and K. Prasad, “Effects of probucol on hypercholesterolemia-induced changes in antioxidant enzymes,” Life Sciences, vol. 58, no. 6, pp. 503–509, 1996. View at Publisher · View at Google Scholar · View at Scopus
  38. K. Prasad, S. V. Mantha, J. Kalra, et al., “Prevention of Hypercholesterolemic Atherosclerosis by Garlic, an Antixoidant,” Journal of Cardiovascular Pharmacology and Therapeutics, vol. 2, pp. 309–320, 1997.
  39. N. Turgan, S. Habif, C. G. Kabaroglu et al., “Effects of the calcium channel blocker amlodipine on serum and aortic cholesterol, lipid peroxidation, antioxidant status and aortic histology in cholesterol-fed rabbits,” Journal of Biomedical Science, vol. 10, no. 1, pp. 65–72, 2003. View at Publisher · View at Google Scholar · View at PubMed