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The Scientific World Journal
Volume 2012 (2012), Article ID 712048, 6 pages
http://dx.doi.org/10.1100/2012/712048
Clinical Study

Cerebrospinal Fluid BACE1 Activity and Brain Amyloid Load in Alzheimer's Disease

1Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Technische Universität München, Ismaninger Street 22, 81675 München, Germany
2Department of Nuclear Medicine, Klinikum rechts der Isar, Technische Universität München, Ismaninger Street 22, 81675 München, Germany

Received 17 October 2011; Accepted 2 November 2011

Academic Editors: E. Ghebremedhin and D. R. Thal

Copyright © 2012 Timo Grimmer et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The secretase BACE1 is fundamentally involved in the development of cerebral amyloid pathology in Alzheimer's disease (AD). It has not been studied so far to what extent BACE1 activity in cerebrospinal fluid (CSF) mirrors in vivo amyloid load in AD. We explored associations between CSF BACE1 activity and fibrillar amyloid pathology as measured by carbon-11-labelled Pittsburgh Compound B positron emission tomography ([11C]PIB PET). [11C]PIB and CSF studies were performed in 31 patients with AD. Voxel-based linear regression analysis revealed significant associations between CSF BACE1 activity and [11C]PIB tracer uptake in the bilateral parahippocampal region, the thalamus, and the pons. Our study provides evidence for a brain region-specific correlation between CSF BACE1 activity and in-vivo fibrillar amyloid pathology in AD. Associations were found in areas close to the brain ventricles, which may have important implications for the use of BACE1 in CSF as a marker for AD pathology and for antiamyloid treatment monitoring.