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Figure 2: Linear regression analysis of fitted and adjusted [11C]PIB uptake and CSF BACE1 activity at the localization of the most significant cluster (Talairach’s coordinates 𝑥 / 𝑦 / 𝑧 1 8 / − 2 4 / − 9 , right parahippocampal gyrus, Brodmann’s area 35), FU: fluorescence units.