Cerebrospinal Fluid BACE1 Activity and Brain Amyloid Load in Alzheimer's Disease

Table 2

Peak correlations between [¹¹C]PIB tracer uptake and CSF BACE1 activity.

Region	𝑥	𝑦	𝑧	𝑍-score	Cluster
Parahippocampal gyrus (r), BA 35	18	−24	−9	3.91	733
Parahippocampal gyrus (l), BA 28	−24	−24	−6	3.58	372
Parahippocampal gyrus (l), BA 35	−14	−13	−28	3.51	235
Thalamus (r)	2	−19	3	3.02	733
Pons (r)	8	−20	−38	3.12	495

Significant brain clusters were labeled in Talairach daemon software (talairach.org/Daemon.html) after conversion of MNI (bic.mni.mcgill.ca) to Talairach’s coordinates using the Matlab function mni2tal (http://imaging.mrc-cbu.cam.ac.uk/imaging/MniTalairach); brain regions are indicated by Talairach’s coordinates; cluster: extent of contiguous voxels within the cluster; r: right, l: left; BA: Brodmann’s area.