Table 2: Peak correlations between [11C]PIB tracer uptake and CSF BACE1 activity.

Region 𝑥 𝑦 𝑧 𝑍 -scoreCluster

Parahippocampal gyrus (r), BA 3518 −24 −9 3.91733
Parahippocampal gyrus (l), BA 28 −24 −24 −6 3.58372
Parahippocampal gyrus (l), BA 35 −14 −13 −28 3.51235
Thalamus (r)2 −19 3 3.02733
Pons (r)8 −20 −38 3.12495

Significant brain clusters were labeled in Talairach daemon software (talairach.org/Daemon.html) after conversion of MNI (bic.mni.mcgill.ca) to Talairach’s coordinates using the Matlab function mni2tal (http://imaging.mrc-cbu.cam.ac.uk/imaging/MniTalairach); brain regions are indicated by Talairach’s coordinates; cluster: extent of contiguous voxels within the cluster; r: right, l: left; BA: Brodmann’s area.