Computational Methods to Work as First-Pass Filter in Deleterious SNP Analysis of Alkaptonuria
Figure 1
Superimposed structures of native and mutant modeled of HGD gene were visualized in stick model using PyMOL release 0.99. (a) Superimposed structure of native amino acid Glycine in sphere shape (blue color) with mutant amino acid Argenine (violet) at position 270 in PDB ID 1EY2 (chain A) of HGD gene with RMSD 1.38 Å. (b) Superimposed structure of native amino acid Argenine in sphere shape (blue color) with mutant amino acid Serine (violet) at position 330 in PDB ID 1EY2 (chain A) of HGD gene with RMSD 1.21 Å. (c) Superimposed structure of native amino acid Valine in sphere shape (blue color) with mutant amino acid Glycine (violet) at position 300 in PDB ID 1EY2 (chain A) of HGD gene with RMSD 1.10 Å.
