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The Scientific World Journal
Volume 2012 (2012), Article ID 821694, 9 pages
http://dx.doi.org/10.1100/2012/821694
Research Article

Diagnostic Value of Software-Based Image Fusion of Computed Tomography and F18-FDG PET Scans in Patients with Malignant Lymphoma

1Department of Radiology, Medical University Innsbruck, 6020 Innsbruck, Austria
2Department of Nuclear Medicine, Medical University Innsbruck, 6020 Innsbruck, Austria
3Division of Hematology and Oncology, Department of Internal Medicine, Medical University Innsbruck, 6020 Innsbruck, Austria

Received 30 October 2011; Accepted 26 December 2011

Academic Editor: Harry Hendrikse

Copyright © 2012 B. Henninger et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Aim. The purpose of this study was to evaluate the accuracy of 2-deoxy-2-[fluorine-18]fluoro-D-glucose (FDG) positron emission tomography (PET), computed tomography (CT), and software-based image fusion of both modalities in the imaging of non-Hodgkin's lymphoma (NHL) and Hodgkin's disease (HD). Methods. 77 patients with NHL ( ๐‘› = 5 8 ) or HD ( ๐‘› = 1 9 ) underwent a FDG PET scan, a contrast-enhanced CT, and a subsequent digital image fusion during initial staging or followup. 109 examinations of each modality were evaluated and compared to each other. Conventional staging procedures, other imaging techniques, laboratory screening, and follow-up data constituted the reference standard for comparison with image fusion. Sensitivity and specificity were calculated for CT and PET separately. Results. Sensitivity and specificity for detecting malignant lymphoma were 90% and 76% for CT and 94% and 91% for PET, respectively. A lymph node region-based analysis (comprising 14 defined anatomical regions) revealed a sensitivity of 81% and a specificity of 97% for CT and 96% and 99% for FDG PET, respectively. Only three of 109 image fusion findings needed further evaluation (false positive). Conclusion. Digital fusion of PET and CT improves the accuracy of staging, restaging, and therapy monitoring in patients with malignant lymphoma and may reduce the need for invasive diagnostic procedures.