Are Ancient Durum Wheats Less Toxic to Celiac Patients? A Study of α-Gliadin from Graziella Ra and Kamut

Table 2

p31–49, DQ2-Glia-α1, DQ2-Glia-α2, DQ2-Glia-α3, and DQ8-Glia-α1 epitopes variants detected in durum wheats under study.

Accession	Locus	p31–49	DQ2-Glia-α1	DQ2-Glia-α2	DQ2-Glia-α3	DQ8-Glia-α1
Cappelli_L	Gli-A2	cs	cs	PQPQLPYSQ	cs	QVSFQPSQLN
Cappelli_S	Gli-A2	LGQQQPFPPQQPYPQPQTF	PFPQPQLPH	PQPQLPHSQ	FRPQQPISQ	QGSFRPSQQN
Flaminio_L	Gli-B2	PGQQQQFPPQQPYPQPQPF	PFP-PQLPY	P-PQLPYPQ	FPPQQPYPQ	QVSFQPSQLN
Flaminio_S	Gli-B2	PGQQQPFPPQQPYPQPQPF	PFP-PQLPY	P-PQLPYPQ	FSPQQPYPQ	cs
Grazia_L	Gli-B2	PGQQQQFPPQQPYPQPQPF	PFP-PQLPY	P-PQLPYPQ	FPPQQPYPQ	QVFFQPSQLN
Grazia_S	Gli-A2	LGQQQQFPPQQPDPQPQPF	cs	PQPQLPYSQ	FRPQQPYLQ	QGFFRPSQQN
Graziella_L	Gli-B2	PGQQQPFPPQQPYPQPQPF	PFP-PQLPY	P-PQLPYPQ	FPTQQPYPQ	QVSFQPSQLN
Graziella_S	Gli-B2	PGQQQPFPPQQPYPQPQPF	PFP-PQLPY	P-PQLPYPQ	FPTQQPYPQ	QGSFQPSQLN
Kamut_L	Gli-B2	PGQQQQFPPQQPYPQPQPF	PFP-PQLPY	P-PQLPYPQ	FPPQQPYPQ	QVSFQPSQLN
Kamut_S	Gli-A2	LGQQQPFPPQQPYPQAQPF	cs	PQPQLPYSQ	cs	QGSFWPSQQN
Svevo_L	Gli-B2	PGQQQQFPPQQPYPQPQPF	PFP-PQLPY	P-PQLPYPQ	FPPQQPYPQ	QVSFQPSQLN
Svevo_S	Gli-B2	PGQQQQFPPQQPYPQPQPF	PFP-PQLPY	P-PQLPYPQ	FSPQQPYPQ	QGFFQPSQQN

Canonical sequences (cs), p31–49: L₁G₂Q₃Q₄Q₅P₆F₇P₈P₉Q₁₀Q₁₁P₁₂Y₁₃P₁₄Q₁₅P₁₆Q₁₇P₁₈F₁₉; DQ2-Glia-α1: P₁(F/Y)₂P₃Q₄P₅Q₆L₇P₈Y₉; DQ2-Glia-α2: P₁Q₂P₃Q₄L₅P₆Y₇P₈Q₉; DQ2-Glia-α3: F₁R₂P₃Q₄Q₅P₆Y₇P₈Q₉; DQ8-Glia-α1: Q₁G₂S₃F₄Q₅P₆S₇Q₈Q₉N₁₀. In bold underlined: aminoacid substitution; hyphen: aminoacid deletion.