Antinociceptive Activity of Ethanol Extract from Duguetia chrysocarpa Maas (Annonaceae)

Table 2

Effect of Dc-EtOH on formalin-induced pain in mice.

Group	Dose (mg/kg)	First phase		Second phase
		Licking time (s)	% inhibition	Licking time (s)	% inhibition
Control	—	72.40±5.77	—	81.17±4.32	—
Dc-EtOH	100	32.00±5.05 **	55.80	57.83±5.82 **	28.75
	200	44.00±1.79 **	39.22	62.80±4.12 **	22.63
	400	37.20±4.95 **	48.62	8.83±3.03 **	89.12
Morphine	10	9.80±4.72 **	86.46	30.00±2.94 **	63.04
Acetylsalicylic acid	150	22.40±3.11 **	69.06	13.17±10.25 **	83.77

Values are mean ± SEM, 𝑛=6. **𝑃<0.01 significantly different from control (ANOVA followed by Dunnett’s test).