Antinociceptive Activity of Ethanol Extract from Duguetia chrysocarpa Maas (Annonaceae)

Table 3

Effect of Dc-EtOH on hot-plate test in mice.

Group	Dose (mg/kg)	Latency time (s)
		30 min	60 min	90 min	120 min
Control	—	5.10±1.10	7.90±1.50	5.30±0.20	5.40±0.60
Dc-EtOH	100	5.20±1.34	6.20±1.02	5.40±0.87	5.80±1.02
	200	5.00±0.80	8.00±1.20	8.00±1.10 *	9.40±1.40 *
	400	4.40±0.40	5.70±1.10	5.40±0.80	6.10±0.80
Morphine	10	19.33±0.67 **	18.00±1.23 **	17.80±1.11 **	14.80±0.86 **

Values are mean ± SEM, 𝑛=6. ^∗𝑃<0,05;^∗∗𝑃<0.01 significantly different from control (ANOVA followed by Dunnett’s test).