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The Scientific World Journal
Volume 2012 (2012), Article ID 895765, 6 pages
http://dx.doi.org/10.1100/2012/895765
Review Article

A Review for Solitary Plasmacytoma of Bone and Extramedullary Plasmacytoma

1Radiation Oncology Clinic, Okmeydani Training and Research Hospital, Ministry of Health, Istanbul, Turkey
2Department of Radiation Oncology, Faculty of Medicine, Celal Bayar University, Manisa, Turkey
3Department of Radiation Oncology, Oncology Institute, Istanbul University, Istanbul, Turkey
4Department of Radiation Oncology, Faculty of Medicine, Ege University, Izmir, Turkey

Received 10 May 2011; Accepted 22 December 2011

Academic Editor: Kenneth C. Anderson

Copyright © 2012 Sevil Kilciksiz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Solitary plasmacytoma (SP) is characterized by a mass of neoplastic monoclonal plasma cells in either bone (SBP) or soft tissue without evidence of systemic disease attributing to myeloma. Biopsy confirmation of a monoclonal plasma cell infiltration from a single site is required for diagnosis. The common presentation of SBP is in the axial skeleton, whereas the extramedullary plasmacytoma (EMP) is usually seen in the head and neck. The ratio of SP seen at males to females is 2 : 1 and the median age of patients is 55 years. The incidence rate of SP in black race is approximately 30% higher than the white race. Incidence rate increases exponentially by advancing age. SBP has a significant higher risk for progression to myeloma, and the choice of treatment is radiotherapy (RT) that is applied with curative intent at min. 4000 cGy. By only RT application, long-term disease-free survival (DFS) is possible for approximately 30% of patients with SBP and 65% of patients with EMP.