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The Scientific World Journal
Volume 2012 (2012), Article ID 925925, 7 pages
http://dx.doi.org/10.1100/2012/925925
Research Article

Synthesis and Anti-Inflammatory Activity of New Alkyl-Substituted Phthalimide 1H-1,2,3-Triazole Derivatives

1Laboratório de Química e Metabolismo de Lipídeos e Lipoproteínas, Departamento de Bioquímica, Universidade Federal de Pernambuco (UFPE), Avenida Prof. Moraes Rego s/n, 50670-420 Recife, PE, Brazil
2Laboratório de Síntese de Compostos Bioativos (LSCB), Departamento de Ciências Moleculares, Universidade Federal Rural de Pernambuco (UFRPE), Rua Dom Manoel de Medeiros s/n, Dois Irmãos, 52171-900 Recife, PE, Brazil

Received 2 October 2012; Accepted 23 October 2012

Academic Editors: A. Brandi, J. H. Li, A. Marra, and G. B. Shul'pin

Copyright © 2012 Shalom Pôrto de Oliveira Assis et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Four new 1,2,3-triazole phthalimide derivatives with a potent anti-inflammatory activity have been synthesized in the good yields by the 1,3-dipolar cycloaddition reaction from N-(azido-alkyl)phthalimides and terminal alkynes. The anti-inflammatory activity was determined by injecting carrageenan through the plantar tissue of the right hind paw of Swiss white mice to produce inflammation. All the compounds 3a–c and 5a–c exhibited an important anti-inflammatory activity; the best activity was found for the compounds 3b and 5c, which showed to be able to decrease by 69% and 56.2% carrageenan-induced edema in mice. These compounds may also offer a future promise as a new anti-inflammatory agent.