Table 1: Acute anti-inflammatory activity of 1,2,3-triazole phthalimides 3a–c and 5a–c after carrageenin-induced edema at dose 250 mg·kg−1.

CompoundsDifference in paw weight (g) ± SEMEdema inhibition (%)

3a0.1030 ± 0.0129**33.7
3b0.0485 ± 0.0160**69.0
3c0.0865 ± 0.0385**44.0
5a0.1247 ± 0.0119**17.0
5b0.1166 ± 0.0308*25.0
5c0.0680 ± 0.0128**56.2
1% Carboxymethylcellulose0.1461 ± 0.0168ns6.0
0.9% saline solution 0.1553 ± 0.0172ns
Ibuprofen0.0421 ± 0.0134**73.0
ASA0.0502 ± 0.0237**68.0

Significant differences: *P < 0.05; **P < 0.001; ns: not significant.