Synthesis and Anti-Inflammatory Activity of New Alkyl-Substituted Phthalimide 1H-1,2,3-Triazole Derivatives

Table 2

Structure activity and log𝑃 values calculated.

Compounds (CH2)𝑛	Structures	log𝑃^∗	Anti-inflammatory activity; (dose 250 mg·Kg^−1)
3a (𝑛=2)		1.53 ± 0.72	33.7
3b (𝑛=3)		1.74 ± 0.71	69.0
3c (𝑛=4)		2.04 ± 0.71	44.0
5a (𝑛=2)		2.37 ± 0.60	17.0
5b (𝑛=3)		2.59 ± 0.60	25.0
5c (𝑛=4)		2.89 ± 0.59	56.2
ASA		1.19 ± 0.23	73.0
Ibuprofen		3.72 ± 0.23	68.0

^∗log𝑃 values were calculated using Advanced Chemistry Development (ACD/Labs Algorithm Version: v5.0.0.184).