Evolution of the C-Type Lectin-Like Receptor Genes of the DECTIN-1 Cluster in the NK Gene Complex

Figure 2

Evolutionary emergence of the C-type lectin-like receptors of the DECTIN-1 cluster. Schematic presentation of the evolutionary emergence of the members of the DECTIN-1 cluster. First transmembrane C-type lectin-like receptors appear in evolutionary old species like urochordates. However, orthologs of receptors of the DECTIN-1 cluster are restricted to mammals. Numbers indicate approximate divergence times in million years. cKLR: cichlid killer cell C-type lectin-like receptors, NKR-P1: natural killer receptor-P1, LLT1: lectin-like transcript-1, MHC: major histocompatibility, mya: million years ago.