Review Article
Biology and Biotechnology of Follicle Development
Table 3
Factors that can promote growth and development of preantral follicles [
2,
3].
| Factor | Origin | Function |
| TNFα | Oocyte | Regulates apoptosis of oocytes | BMP15 | Oocyte | Differentiation and proliferation of primary follicles | GDF 9 | Oocyte | Differentiation and proliferation of primary follicles | EGF/bFGF | Oocyte | Induces development of primordial and preantral follicles | Figα (Figla) | Oocyte | Coordination of structural genes for development of the primordial follicle such as Zp1, Zp2, and Zp3 of the ZP | Protein ckit | Oocyte and theca | Transition of primordial follicle to primary follicle. Migration and proliferation of germ cells | Activin | Granulosa cells | Proliferation of granulosa cells | KL | Pregranulosa cells | Induces development of primordial follicle to primary follicle | GH | Endocrine | Development of GC and theca cells of preantral follicles | Insulin | Endocrine | Induces development of the primordial follicle to primary follicle | IGF-I | Granulosa cells | Stimulates development from preantral follicle to antral follicle | AMH | Granulosa cells | Inhibition of primordial follicle development | AhR | Granulosa cells | Regulation of the oocyte pool size | BMP4 | Theca/stroma | Promotes transition from primordial follicle to primary follicle and oocyte survival | KGF | Theca | Proliferation of granulosa cells |
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AhR: Aromatic hydrocarbon receptor, AMH: anti-Mullerian hormone, BMP: bone morphogenic protein, EGF/bFGF: epidermis growth factor/basic fibroblast growth factor, GDF: growth differentiation factor, GH: growth hormone, Figα: factor in the germline alpha, IGF: insulin growth factor, KGF: keratinocyte growth factor, KL: Kit ligand, TNF: tumor necrosis factor.
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