Research Article

HER-2 Expression in Immunohistochemistry Has No Prognostic Significance in Gastric Cancer Patients

Table 1

Two procedures for evaluation of HER-2 expression.

Percentage of positive cellsIRS (Immunoreactive Score) modified by authorsaPoints
PointsIntensity of reaction

No positive cells0No reaction0
<25% positive cells1Weak colour reaction1
25–50% positive cells2Moderate intensity2
51–75% positive cells3Intense reaction3
>75% positive cells4

Consensus recommendations on HER-2 scoring for gastric cancerb

DefinitionScore
No reactivity or membranous reaction in <10% of cells0
Faint complete or partial membranous reactivity in >10% of cells1+
Moderate complete or basolateral membranous reactivity in >10% of cells2+
Strong complete or basolateral membranous reactivity in >10% of cells3+

a IRS score (Immunoreactive Score) according to Remmele and Stegner [15] modified by authors
bHercep test criteria modified by Hofmann et al. [16] for gastric cancer.