Research Article

HER-2 Expression in Immunohistochemistry Has No Prognostic Significance in Gastric Cancer Patients

Table 4

Multivariate Cox proportional hazard regression analysis of HER-2 expression and clinicopathological parameters influence on patients overall survival.

Clinicopathological parameters 𝑃 -value

Age0.014
Nodal metastases (pN)0.003
Tumor size (pT)0.027
Hercep test scorea0.775
Percentage of positive HER-2 cancer cellsb0.741
Intensity of HER-2 color reaction (I)c0.859
HER-2 IRSd0.321

aHercep test criteria modified by Hofmann et al. [16] for gastric cancer.
bPercentage of HER-2-positive gastric cancer cells (%) according to Remmele et al. [15] modified by authors.
cIntensity of immunohistochemical reaction in cancer cells (I) according to Remmele and Stegner [15] modified by authors.
dIRS score (ImmunoReactive Score) according to Remmele and Stegner [15] modified by authors.